Analytical Data
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Gene name
TOMM70A
- Application
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Alternative Names
TOM70A; Mitochondrial precursor proteins import receptor; Mitochondrial import receptor subunit TOM70; Translocase of outer membrane 70 kDa subunit
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94826
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Expression Region
Leu333~Leu608
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Molecular Weight
35kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TOMM70A, or Translocase of Outer Mitochondrial Membrane 70A, is a vital protein involved in the import of mitochondrial proteins, particularly those encoded by nuclear DNA. Its significance has garnered attention in the context of mitochondrial biogenesis and homeostasis, given that mitochondrial dysfunction is implicated in various diseases, including neurodegenerative disorders and cancer. The TOM complex serves as the initial gateway for protein transport into mitochondria, and TOMM70A plays a crucial role by recognizing and binding precursor proteins, facilitating their translocation across the mitochondrial outer membrane. Recent studies have indicated that TOMM70A is not only essential for maintaining mitochondrial function but may also have implications in apoptosis and cell survival. Mutations or dysregulation of TOMM70A have been linked to a variety of mitochondrial diseases, raising the need for a deeper understanding of its structure and function. Furthermore, the study of TOMM70A as a potential therapeutic target is gaining traction, as enhancing its activity or restoring its function may offer novel strategies for treating mitochondrial-related pathologies. Thus, research on TOMM70A and its recombinant forms is critical for elucidating mitochondrial dynamics and developing targeted interventions for associated diseases.
