Analytical Data
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基因名
TOMM70A
- Application
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别名
TOM70A; Mitochondrial precursor proteins import receptor; Mitochondrial import receptor subunit TOM70; Translocase of outer membrane 70 kDa subunit
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94826
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表达区间
Leu333~Leu608
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分子量
35kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TOMM70A, or Translocase of Outer Mitochondrial Membrane 70A, is a vital protein involved in the import of mitochondrial proteins, particularly those encoded by nuclear DNA. Its significance has garnered attention in the context of mitochondrial biogenesis and homeostasis, given that mitochondrial dysfunction is implicated in various diseases, including neurodegenerative disorders and cancer. The TOM complex serves as the initial gateway for protein transport into mitochondria, and TOMM70A plays a crucial role by recognizing and binding precursor proteins, facilitating their translocation across the mitochondrial outer membrane. Recent studies have indicated that TOMM70A is not only essential for maintaining mitochondrial function but may also have implications in apoptosis and cell survival. Mutations or dysregulation of TOMM70A have been linked to a variety of mitochondrial diseases, raising the need for a deeper understanding of its structure and function. Furthermore, the study of TOMM70A as a potential therapeutic target is gaining traction, as enhancing its activity or restoring its function may offer novel strategies for treating mitochondrial-related pathologies. Thus, research on TOMM70A and its recombinant forms is critical for elucidating mitochondrial dynamics and developing targeted interventions for associated diseases.
