Analytical Data
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基因名
PCMT1
- Application
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别名
PIMT; L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22061
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表达区间
Ala2~Lys227
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分子量
28kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCMT1 (Protein-L-isoaspartate O-methyltransferase 1) is an important enzyme involved in the repair of damaged proteins, specifically those that have undergone isoaspartate formation, a common occurrence during protein aging and stress. The accumulation of isoaspartate residues can severely affect protein function, leading to cellular dysfunction and contributing to various diseases, including neurodegenerative disorders. Research on PCMT1 has gained interest due to its potential role in maintaining protein homeostasis and its implications in aging and disease mechanisms. Recombinant PCMT1 protein is often produced for in-depth studies to elucidate its enzymatic mechanisms, substrate specificity, and regulatory pathways. Understanding the structure and function of PCMT1 not only provides insights into its biological significance but also opens avenues for therapeutic interventions aimed at modulating its activity in disease contexts. Additionally, PCMT1 is a promising candidate for developing biomarkers for age-related diseases, thereby enhancing our understanding of age-associated pathologies. As such, the study of recombinant PCMT1 presents a valuable opportunity to advance our knowledge in protein repair mechanisms and explore its potential as a target for developing novel therapeutic strategies.
