Analytical Data
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Gene name
MCM3AP
- Application
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Alternative Names
GANP; MAP80; Germinal-center associated nuclear protein; 80 kDa MCM3-associated protein; MCM3 acetyltransferase; MCM3 acetylating protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60318
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Expression Region
Phe33~Arg340
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Molecular Weight
39kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MCM3AP, or Minichromosome Maintenance 3 Associated Protein, is a crucial protein involved in DNA replication and cellular proliferation. It serves as an essential cofactor for the MCM (Minichromosome Maintenance) complex, which is vital for the initiation of DNA replication in eukaryotic cells. The significance of MCM3AP in promoting genome stability and facilitating proper DNA replication has garnered attention in the field of molecular biology and cancer research. Abnormalities in its expression or function have been associated with various malignancies, suggesting that MCM3AP can influence tumorigenesis and cellular response to DNA damage. Furthermore, understanding the molecular mechanisms underlying MCM3AP interactions with the MCM complex and other regulatory proteins is critical for elucidating its role in the cell cycle and potential implications for therapeutic strategies in cancer treatment. As researchers continue to explore the functional aspects of MCM3AP, it is hoped that insights gained will lead to the development of innovative approaches for targeting DNA replication processes in cancer cells, thereby offering new avenues for therapeutic intervention.
