Analytical Data
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基因名
MAP3K7IP1
- Application
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别名
TAB1; TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1; TAK1-Binding Protein 1; TGF-beta-activated kinase 1-binding protein 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15750
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表达区间
Leu189~Pro439
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP3K7IP1, also known as TAK1-binding protein 1 (TAB1), is a critical player in the regulation of signaling pathways that control various biological processes, including cell proliferation, differentiation, and immune responses. This protein acts as a scaffold in the Transforming Growth Factor-beta (TGF-β) signaling pathway and facilitates the activation of Mitogen-Activated Protein Kinase (MAPK) pathways, which are essential for mediating cellular responses to stress and inflammation. Given its important role in these pathways, dysregulation of MAP3K7IP1 has been implicated in various diseases, including cancer, autoimmune disorders, and cardiovascular diseases. In recent years, researchers have focused on the recombinant expression of MAP3K7IP1 to elucidate its functional mechanisms and interactions. By producing this protein in host systems, scientists can study its biochemical properties, structural characteristics, and role in cellular signaling. This research not only enhances our understanding of MAP3K7IP1’s function in normal and pathological conditions but also opens up potential avenues for therapeutic interventions targeting its pathways. As such, the study of recombinant MAP3K7IP1 is vital for advancing our knowledge of cellular signaling networks and their implications in health and disease.
