Analytical Data
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Gene name
PACSIN2
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简介
The PACSIN2 protein coordinates caveolar morphogenesis and endocytosis to dynamically regulate cell membrane structure. As a lipid-binding protein, PACSIN2 regulates phosphatidic acid-containing membranes. PACSIN2 Protein, Human (HEK293, His) is the recombinant human-derived PACSIN2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Protein Kinase C and Casein Kinase Substrate in Neurons Protein 2; PACSIN2
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UNF0-1
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Expression Region
M1-Q486
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AA Sequence
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEAIQ
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Protein Length
Full Length of Isoform-1
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Molecular Weight
88 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PACSIN2, or Protein kinase C and casein kinase substrate in neurons 2, is a member of the PACSIN protein family, which plays a crucial role in the regulation of synaptic vesicle trafficking and endocytosis in neuronal cells. Recent studies have highlighted its significant involvement in various cellular processes, such as cytoskeletal dynamics, membrane curvature, and signal transduction, making it a key player in neurotransmitter release and synaptic plasticity. Given its importance in neuronal function, PACSIN2 has been implicated in several neurological disorders, including neurodegenerative diseases and psychiatric disorders. The recombinant study of PACSIN2 aims to provide deeper insights into its structural and functional properties, allowing researchers to explore its interaction with other proteins and its role in cellular signaling pathways. By generating and characterizing PACSIN2 recombinant proteins, scientists hope to elucidate its biological functions, investigate potential therapeutic targets, and understand its involvement in the pathogenesis of neurobiological conditions. This research not only enhances our comprehension of basic neuronal processes but also holds promise for developing strategies to mitigate the impact of PACSIN2-related disorders.
