Analytical Data
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Gene name
SDHC
- Application
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Alternative Names
PGL3; CYB560, SDH3; CYBL; QPs1; Integral membrane protein CII-3; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; Succinate dehydrogenase cytochrome b560
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Species
Mouse
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9CZB0
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Expression Region
Met1~Arg72
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Molecular Weight
42kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of SDHC (succinate dehydrogenase complex subunit C) recombinant proteins is rooted in the increasing recognition of the role of mitochondrial dysfunction in various metabolic disorders and cancer. SDHC is one of the four subunits of the succinate dehydrogenase (SDH) enzyme, which is essential for the tricarboxylic acid (TCA) cycle and the electron transport chain in mitochondria. Mutations in the SDHC gene are linked to hereditary paraganglioma and pheochromocytoma syndromes, highlighting its importance in genetic predisposition to certain tumors. Research has shown that dysfunctional SDH leads to the accumulation of succinate, which can act as an oncometabolite, promoting cancer cell proliferation and survival. Furthermore, the exploration of SDHC recombinant proteins allows for the study of the biochemical properties and interactions of the SDH complex in a controlled setting, facilitating the understanding of its function and regulation within cellular metabolism. By generating recombinant SDHC, researchers can investigate its role in mitochondrial pathways, assess the impact of specific mutations, and potentially develop therapeutic strategies for diseases associated with SDH dysfunction. As a result, the study of SDHC recombinant proteins is an essential aspect of mitochondrial biochemistry and cancer research, aiming to unravel the complexities of metabolic regulation and its implications for health and disease.
