Analytical Data
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Gene name
SATB1
- Application
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Alternative Names
DNA-binding protein SATB1; Special AT-Rich Sequence Binding Protein 1(Binds To Nuclear Matrix/Scaffold-Associating DNA's)
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q01826
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Expression Region
Thr72~Gln445
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Molecular Weight
46kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SATB1 (Special AT-rich sequence-binding protein 1) is a nuclear matrix protein that plays a crucial role in the regulation of gene expression and the structural organization of the genome. It is known for its ability to bind to AT-rich DNA sequences, thereby influencing chromatin architecture and facilitating the formation of higher-order genomic structures. Research has shown that SATB1 acts as a global regulator of gene expression, particularly during critical developmental processes and in response to environmental stimuli. Its dysregulation has been associated with various diseases, including cancer and autoimmune disorders, making it a significant target for therapeutic intervention. The study of SATB1 recombinant proteins provides insights into its functional mechanisms and interactions with DNA and other nuclear components. By understanding the protein's binding properties and the pathways it influences, researchers aim to unravel its roles in disease progression and potential therapeutic applications. Moreover, recombinant SATB1 proteins serve as valuable tools for investigating chromatin dynamics, gene regulatory networks, and the broader implications of genomic organization in health and disease.
