Analytical Data
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基因名
AHRR
- Application
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别名
AHH; AHHR; BHLHE77; Aryl Hydrocarbon Receptor Regulator; Class E basic helix-loop-helix protein 77
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A9YTQ3
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表达区间
Met1~Pro182
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分子量
50kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AHRR (Aryl Hydrocarbon Receptor Repressor) is a crucial protein involved in the regulation of the aryl hydrocarbon receptor (AHR) pathway, which plays a significant role in mediating the effects of environmental pollutants, such as dioxins and polycyclic aromatic hydrocarbons. The research into AHRR is particularly important due to its potential implications in various biological processes, including immune response, cellular growth, and differentiation. Dysregulation of the AHR signaling pathway has been associated with several pathologies, including cancer, metabolic disorders, and developmental issues. AHRR functions primarily as a transcriptional repressor, counteracting AHR activation by binding to the same response elements in DNA, thereby inhibiting the expression of AHR-target genes. Understanding the mechanisms underlying AHRR's action and its interaction with AHR is crucial for developing therapeutic strategies targeting AHR-related diseases. Moreover, recent studies have highlighted the potential role of AHRR in modulating the effects of environmental toxins and its contribution to individual susceptibility to exposure-related health effects. Research on AHRR and its recombinant forms has enabled scientists to explore not only its biological significance but also its potential application in biomedicine and environmental health. Consequently, the expansion of knowledge surrounding AHRR's function and its implications in various research areas underscores the importance of further studies to elucidate its role in health and disease.
