Analytical Data
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Gene name
TKTL1
- Application
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Alternative Names
TKR; TKT2; TK 2; Transketolase-related protein; Transketolase 2
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51854
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Expression Region
Met1~Asp259
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Molecular Weight
59kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TKTL1 (transketolase-like 1) is an enzyme that plays a critical role in the non-oxidative phase of the pentose phosphate pathway, which is essential for cellular metabolism and biosynthesis of nucleotides and amino acids. This enzyme has gained significant attention in recent years due to its upregulation in various types of cancer, suggesting that it may contribute to the metabolic reprogramming associated with tumor growth and survival. Elevated TKTL1 expression has been linked to increased cell proliferation and resistance to apoptosis, thus making it a potential biomarker for cancer diagnosis and prognosis. Researchers have been focusing on the recombinant production of TKTL1 protein to better understand its structure, function, and implications in cancer metabolism. By producing TKTL1 as a recombinant protein, scientists can elucidate its enzymatic characteristics and interactions with other metabolic pathways, allowing for the development of targeted therapeutic strategies. Additionally, studying the recombinant TKTL1 offers insights into its potential role in metabolic disorders beyond cancer, highlighting its significance in pathology and as a possible target for drug development. Through functional assays, structural analysis, and interaction studies, research on TKTL1 may pave the way for novel interventions that could inhibit tumor growth by disrupting its metabolic dependencies. This burgeoning field underscores the importance of TKTL1 in cancer research and its potential as a target for innovative therapeutic approaches.
