Analytical Data
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Gene name
TP53BP1
- Application
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Alternative Names
53BP1; p53BP1; p202
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q12888
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Expression Region
Leu1724~Lys1964
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TP53BP1 (Tumor Protein p53 Binding Protein 1) is a critical protein involved in the cellular response to DNA damage and plays a significant role in maintaining genomic stability. It is primarily known for its function in the DNA repair pathway, particularly in recognizing and responding to double-strand breaks through its interaction with the p53 tumor suppressor protein. The relevance of TP53BP1 has gained attention due to its implications in cancer biology, where mutations or dysregulation can lead to tumorigenesis and affect the efficacy of cancer therapies. Research into recombinant TP53BP1 has become a focal point for understanding its structural and functional properties, which may facilitate the development of novel therapeutic strategies targeting DNA repair mechanisms. Advancements in techniques such as gene editing and protein engineering allow scientists to create recombinant forms of TP53BP1 for detailed study, exploring aspects such as its interaction with other proteins, its role in the DNA damage response (DDR), and how it influences cell cycle regulation. Moreover, understanding TP53BP1's function in various cancer types could unveil potential biomarkers for prognosis and treatment response, making it a pivotal target in the pursuit of personalized medicine. As such, the detailed exploration of recombinant TP53BP1 not only contributes to fundamental knowledge in molecular biology but also holds promise for innovative cancer therapies and improved patient outcomes.
