Analytical Data
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Gene name
UBQLN2
- Application
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Alternative Names
CHAP1; CHAP1/DSK2; Dsk2; LIC-2; N4BP4; PLIC-2; PLIC2; NEDD4 Binding Protein 4; Protein linking IAP with cytoskeleton 2; Ubiquitin-like product Chap1/Dsk2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UHD9
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Expression Region
Ile33~Ala126
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Molecular Weight
14kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UBQLN2 (Ubiquilin 2) is a multifunctional protein that plays a crucial role in the regulation of protein degradation and cellular quality control by shuttling ubiquitinated proteins to the proteasome for degradation. Research has increasingly focused on UBQLN2 due to its involvement in various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in the UBQLN2 gene have been implicated in the familial forms of ALS, suggesting its significant role in neurodegeneration. The study of recombinant UBQLN2 protein is essential to understand its structural and functional properties, which may provide insights into its mechanism of action and how mutations affect its function. By generating and characterizing this recombinant protein, researchers aim to dissect its interaction with other cellular pathways, particularly those involving protein aggregation and degradation processes. Furthermore, understanding UBQLN2’s role in maintaining proteostasis could pave the way for potential therapeutic strategies targeting the protein misfolding and aggregation seen in neurodegenerative diseases. Overall, the investigation of UBQLN2 recombinant protein is a vital area of study that bridges molecular biology and neurobiology, with the potential to unveil new targets for treating debilitating neurological disorders.
