Analytical Data
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Gene name
TYROBP
- Application
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Alternative Names
DAP12; KARAP; PLOSL; Killer Activating Receptor Associated Protein; DNAX-Activation Protein 12
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43914
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Expression Region
Leu22~Lys113
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Molecular Weight
42kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TYROBP, also known as TYRO protein tyrosine kinase binding protein, has gained attention in recent years due to its critical role in immune cell signaling and its involvement in various pathological conditions. This adaptor protein interacts with several immunoreceptors and signaling molecules, playing a pivotal role in modulating immune responses, especially within myeloid cells like macrophages and dendritic cells. Research has linked dysregulation of TYROBP to autoimmune diseases, cancer, and neurodegenerative disorders, highlighting its potential as a therapeutic target. In particular, the study of TYROBP recombinant proteins has become a focal point for understanding its structural and functional properties, aiding in the elucidation of its signaling pathways. By producing and characterizing TYROBP recombinant proteins, researchers aim to further investigate its interactions with other proteins and its impact on immune cell activation. This knowledge may provide valuable insights into the development of novel immunotherapies and the design of targeted treatments for TYROBP-related diseases. Overall, TYROBP serves as a crucial component in the immune system, making its study paramount for advancing therapeutic strategies in various health conditions.
