Analytical Data
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基因名
ATP2C1
- Application
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别名
ATP2C1A; BCPM; HHD; PMR1; SPCA1; hSPCA1; Benign Chronic Pemphigus(Hailey-Hailey Disease); Secretory Pathway Ca2+/Mn2+ ATPase 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P98194
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表达区间
Met1~Pro70
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分子量
15kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP2C1, also known as ATPase cation-transporting 2C1, is a P-type ATPase that plays a crucial role in the regulation of intracellular calcium levels and magnesium homeostasis. Mutations in the ATP2C1 gene are associated with a range of diseases, most notably Hailey-Hailey Disease (HHD), which is characterized by the formation of blisters and lesions on the skin. Research into ATP2C1 recombinant proteins has gained traction in the last few decades, as understanding its structure and function is essential for elucidating the mechanisms of calcium and magnesium transport in cells and the pathophysiology of related disorders. The production of recombinant ATP2C1 allows for detailed biochemical studies, providing insights into its enzymatic activity, regulatory mechanisms, and interaction with other cellular proteins. Furthermore, investigating this protein could contribute to the development of potential therapeutic strategies, including gene therapy or small molecular inhibitors, to treat conditions associated with ATP2C1 dysfunction. The advent of advanced techniques in protein expression and purification has facilitated the study of ATP2C1, positioning it as a significant target for ongoing research in cellular signaling, ion transport, and the treatment of skin diseases linked to its mutation.
