Analytical Data
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Gene name
Cadherin-19
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简介
CDH19 Protein, a calcium-dependent cell adhesion protein, engages in homophilic interactions, primarily connecting cells. This adhesive property suggests a potential role for cadherins, including CDH19, in facilitating the sorting of diverse cell types. CDH19 Protein, Human (Flag-MBP) is the recombinant human-derived CDH19 protein, expressed by E. coli , with N-MBP, N-Flag labeled tag.
- Application
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Alternative Names
Cadherin-19; Cadherin19; CDH7L2; cad19
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Species
Human
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Source
E. coli
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Tag
N-MBP;N-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H159-1
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Expression Region
G44-H569
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Protein Length
Partial
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Molecular Weight
100.89 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cadherin-19 is a member of the cadherin superfamily of proteins, which are integral in mediating cell-cell adhesion and are crucial for the development and maintenance of tissue architecture. Specifically, Cadherin-19 is predominantly expressed in the nervous system and has been implicated in neuronal development, synaptic plasticity, and the establishment of neural networks. Abnormalities in cadherin-19 expression or function have been associated with various neurological disorders, including autism spectrum disorders and epilepsy. The study of Cadherin-19 is particularly significant due to its potential role in neurodevelopmental processes and its contribution to understanding the molecular mechanisms underlying brain function and pathology. Researchers aim to produce recombinant Cadherin-19 proteins for structural and functional analysis, which can lead to insights into its adhesive properties and interactions with other cellular components. By utilizing recombinant DNA technology, scientists can elucidate the functional domains of Cadherin-19 and explore its roles in cell signaling and adhesion. This research not only enhances our understanding of cadherin biology but also holds promise for novel therapeutic approaches targeting cadherin-related pathways in neurodevelopmental and neuropsychiatric disorders.
