Analytical Data
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Gene name
PSMC4
- Application
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Alternative Names
S6; TBP7; Protease 26S subunit 6; MB67-interacting protein; Tat-Binding Protein 7; MB67 Interacting Protein; 26S proteasome AAA-ATPase subunit RPT3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43686
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Expression Region
Met1~Lys418
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Molecular Weight
51kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMC4, a component of the 26S proteasome, plays a crucial role in the ubiquitin-proteasome pathway, which is vital for protein degradation and regulation of various cellular processes, including the cell cycle, signal transduction, and stress responses. Research into PSMC4 has gained attention due to its potential implications in cancer progression and other diseases, as it is involved in the regulation of tumor suppressors and oncoproteins. Understanding the structure and function of PSMC4 can provide insights into its role in cellular homeostasis and disease mechanisms. Additionally, PSMC4 has been linked to cellular responses to environmental stress, making it a key focus for studies related to aging and neurodegenerative disorders. Recent advancements in structural biology techniques, such as cryo-electron microscopy, have facilitated deeper exploration of PSMC4's conformational dynamics and interactions within the proteasome complex. This research not only enhances our understanding of protein degradation pathways but also opens avenues for targeted therapeutic strategies aimed at modulating PSMC4 activity in various pathological conditions. Overall, PSMC4 serves as a pivotal point of interest in modern biological research, with significant implications for the development of novel treatments for a range of diseases, particularly those linked to dysregulation of protein homeostasis.
