Analytical Data
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Gene name
PSMb6
- Application
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Alternative Names
LMPY; Macropain delta chain; Proteasome subunit Y; Multicatalytic endopeptidase complex delta chain
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28072
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Expression Region
Ala2~Ala239
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMb6 is a component of the 26S proteasome, a crucial multi-subunit complex responsible for protein degradation in eukaryotic cells. This proteasome plays a vital role in regulating various cellular processes, including the cell cycle, signaling pathways, and the removal of damaged or misfolded proteins. The PSMb6 subunit, specifically, is involved in the assembly and function of the proteasome complex, impacting its efficiency and specificity in substrate recognition and degradation. Recent studies have highlighted the importance of PSMb6 in maintaining cellular homeostasis and its potential implications in cancer biology, where dysregulation of proteasomal activity is often observed. Furthermore, research into the recombinant production of PSMb6 has gained traction, as the availability of high-purity protein is essential for elucidating its structure-function relationships and therapeutic potential. By producing recombinant PSMb6, researchers aim to investigate its role in proteasomal activity, explore its interactions with other proteasome components, and assess its impact on the degradation of specific substrates. Understanding these mechanisms could pave the way for novel therapeutic strategies targeting proteasomal dysfunction in various diseases, including cancer and neurodegenerative disorders.
