Analytical Data
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基因名
NOX4
- Application
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种属
Pongo abelii
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5R5C5
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表达区间
1-578aa
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分子量
69.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOX4 (NADPH oxidase 4) is an important member of the NADPH oxidase family, predominantly expressed in endothelial cells and various types of tissues. It plays a crucial role in reactive oxygen species (ROS) generation, which contributes to cellular signaling and adaptation to oxidative stress. Elevated NOX4 activity has been implicated in various cardiovascular diseases, including hypertension, atherosclerosis, and heart failure, as it can lead to oxidative damage and inflammation. Researchers have increasingly focused on NOX4 as a potential therapeutic target, given its involvement in pathological conditions. The recombinant expression of NOX4 allows for detailed studies of its enzymatic properties, regulatory mechanisms, and interactions with other cellular proteins. Additionally, recombinant NOX4 can be utilized in drug screening and the development of inhibitors aimed at modulating its activity. Understanding the structure-function relationship of NOX4 through recombinant protein techniques can lead to novel insights into its role in disease mechanisms and therapeutic strategies. As a result, the study of NOX4 recombinant protein holds great promise for advancing our knowledge of oxidative stress-related diseases and developing targeted interventions.
