Analytical Data
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基因名
FOXD3
- Application
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别名
HFH2; AIS1; FOX-D3; Genesis; HNF3/FH transcription factor genesis
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
F1LSL0
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表达区间
Gln244~Phe479
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分子量
32kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOXD3 is a forkhead box transcription factor playing a crucial role in the regulation of embryonic development and stem cell maintenance. It is particularly significant in the context of pluripotency and lineage specification, influencing the fate of embryonic and adult stem cells. Research into FOXD3 has gained momentum due to its potential implications in regenerative medicine and cancer biology. Studies have demonstrated that FOXD3 can modulate key signaling pathways involved in cell differentiation and survival, making it a critical player in early development. Additionally, FOXD3 expression has been linked to various malignancies, where it may contribute to tumorigenesis and the maintenance of cancer stem cell properties. The manipulation of FOXD3 expression, using recombinant proteins, holds promise for therapeutic strategies aimed at enhancing tissue regeneration or targeting cancer stem cells. By further investigating the biophysical properties and functional roles of recombinantly expressed FOXD3, researchers hope to elucidate its mechanisms of action and identify potential interventions that can harness its regulatory effects in both developmental and pathological contexts.
