Analytical Data
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Gene name
AP1m1
- Application
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Alternative Names
AP47; CLAPM2; CLTNM; MU-1A; Clathrin assembly protein complex 1 mu-1 medium chain 1; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; Mu1A-adaptin
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXS5
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Expression Region
Ser2~Pro258
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Molecular Weight
32kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP1m1, or Adaptor Protein 1 Gamma 1, is a crucial component of the clathrin-coated vesicle (CCV) formation process, which plays a key role in intracellular trafficking and membrane dynamics. Research on AP1m1 has gained prominence due to its involvement in various cellular functions, including endocytosis, protein sorting, and signaling pathways. Mutations or dysregulation of AP1m1 have been linked to a range of diseases, including neurodegenerative disorders and certain cancers, underscoring its importance in maintaining cellular homeostasis. The reconstruction of AP1m1 protein has become a pivotal focus within molecular biology and biochemistry, enabling researchers to elucidate its structural and functional properties and understand its interactions with other proteins in the cell. Studying the recombinant form of AP1m1 allows scientists to investigate its role in the formation of AP1 complexes and clathrin-mediated transport. Furthermore, by elucidating the mechanisms of AP1m1 function, researchers aim to develop therapeutic strategies targeting its pathways, potentially leading to novel treatments for diseases associated with its malfunction. Understanding the biochemistry of AP1m1 and its role in cellular mechanisms is thus vital for identifying how its alteration can impact overall cellular function and contribute to pathologies.
