Analytical Data
-
Gene name
AP1s2
- Application
-
Alternative Names
DC22; SIGMA1B; MRX59; Mental Retardation,X-Linked 59; Clathrin assembly protein complex 1 sigma-1B small chain; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P56377
-
Expression Region
Met1~Thr157
-
Molecular Weight
22kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
AP1s2, or Adaptor Protein Complex 1, is a critical component of the cellular machinery involved in intracellular trafficking, particularly in the sorting and transport of proteins within the cell. This protein plays a key role in the formation of clathrin-coated vesicles, which are essential for the endocytosis and transport of membrane proteins and lipids. Recent studies have highlighted the importance of AP1s2 in various cellular processes, including endosomal trafficking, receptor recycling, and signal transduction pathways. The dysfunction of AP1s2 has been implicated in various diseases, such as neurodegenerative disorders and cancer, where altered protein trafficking can lead to cellular dysfunction and disease progression. Research on AP1s2 recombinant proteins seeks to elucidate its structure-function relationship and its interaction with other cellular components. By producing and studying recombinant AP1s2, scientists aim to gain insights into its role in cellular homeostasis and to explore its potential as a therapeutic target. Understanding the mechanisms underlying AP1s2 function could pave the way for novel strategies in treating diseases associated with trafficking defects, thereby underscoring the significance of this protein in cellular biology and medicine.
