Analytical Data
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Gene name
ADORA2b
- Application
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Species
Human
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Source
E. coli
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Tag
Two N- s, His- & SUMO-
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29275
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Expression Region
Gln260~Leu332
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Molecular Weight
19kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADORA2b, a subtype of the adenosine receptor family, plays a critical role in various physiological processes, including modulation of inflammation, immune responses, and cardiovascular functions. It is a G protein-coupled receptor (GPCR) that primarily interacts with adenosine, a nucleoside involved in cellular energy transfer and signaling. This receptor's activation has been linked to several pathophysiological conditions, such as cancer progression, chronic inflammatory diseases, and cardiovascular disorders. Research into recombinant ADORA2b protein focuses on understanding its structure, signaling pathways, and functional roles in different biological contexts. By producing ADORA2b in recombinant systems, scientists aim to elucidate its mechanisms of action and potential as a therapeutic target. Additionally, the study of this receptor can facilitate the development of novel drugs that modulate its activity, offering new avenues for treatment in conditions where adenosine signaling is disrupted. Overall, the investigation of ADORA2b recombinant proteins is a pivotal aspect of contemporary biomedical research, aiming to unlock new insights into receptor pharmacology and its implications for human health.
