Analytical Data
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基因名
RNF182
- Application
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别名
E3 ubiquitin-protein ligase RNF182; RNF182; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N6D2
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表达区间
M1-R183
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氨基酸序列
MASQPPEDTAESQASDELECKICYNRYNLKQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGGKGKKCLPENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDSVTTVSHNWTVWNCTSLLFQTSIR
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蛋白长度
Partial
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分子量
28-33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF182, a member of the RING finger protein family, has garnered interest in recent years due to its potential roles in various cellular processes, including cell proliferation, apoptosis, and DNA damage response. As a ubiquitin E3 ligase, RNF182 is involved in the ubiquitination pathway, which is crucial for protein degradation and regulation within the cell. Dysregulation of ubiquitination processes is often linked to various diseases, including cancer. Research has shown that RNF182 interacts with several key proteins involved in signaling pathways that govern these cellular processes, suggesting its significance in maintaining cellular homeostasis. Furthermore, studies indicate that RNF182 may have implications in the modulation of immune responses and has been associated with the regulation of transcription factors. Despite its emerging importance, the detailed functional mechanisms of RNF182 and its full spectrum of biological roles remain to be elucidated. Investigating recombinant RNF182 proteins can help in deciphering its specific functions, interactions, and potential therapeutic targetability in diseases such as cancer, making it a valuable focus for ongoing research in molecular biology and oncology.
