Analytical Data
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Gene name
DOK7
- Application
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Alternative Names
C4orf25; Downstream of tyrosine kinase 7
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
D3ZDW9
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Expression Region
Trp63~Gly320
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Molecular Weight
34kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DOK7, or Docking Protein 7, is a pivotal protein involved in neuromuscular junction (NMJ) formation and maintenance, playing a critical role in the signaling pathways of muscle cells and their interaction with motor neurons. Research on DOK7 has garnered attention due to its association with congenital myasthenic syndromes, a group of genetic disorders characterized by muscle weakness and fatigability. Mutations in the DOK7 gene can lead to impaired transmission at the NMJ, resulting in severe muscle dysfunction. Investigating DOK7 through the study of recombinant proteins has become essential for understanding its structural and functional properties. By producing and characterizing DOK7 recombinant proteins, researchers aim to elucidate the mechanisms by which DOK7 regulates acetylcholine receptor clustering and stabilizes the NMJ. Additionally, exploring the protein's interactions with other signaling molecules and receptors provides insights into potential therapeutic targets for muscle disorders. This research not only enhances our understanding of the fundamental biology of neuromuscular transmission but also paves the way for developing innovative treatments for conditions stemming from DOK7 dysfunction. As such, the study of DOK7 recombinant proteins serves as a crucial foundation for both basic and applied biomedical research.
