Analytical Data
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Gene name
FGF basic/bFGF
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简介
FGF2 protein is a multifunctional ligand that can bind to FGFR1, FGFR2, FGFR3 and FGFR4. It is also a key integrin ligand for FGF2 signal transduction and has an important interaction with the integrin ITGAV:ITGB3. FGF2 plays a critical role in cell survival, division, differentiation, and migration, serves as a potent mitogen, and induces angiogenesis. FGF basic/bFGF protein, Bovine (P. pastoris, N-His) is the recombinant bovine-derived FGF2 protein, expressed by P. pastoris , with N-6*His labeled tag.
- Application
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Alternative Names
Fibroblast Growth Factor 2; FGF-2; Basic Fibroblast Growth Factor; bFGF; Heparin-Binding Growth Factor 2; HBGF-2; Fgf2; Fgf-2
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Species
Bovine
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Source
P. pastoris
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P03969
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Expression Region
P10-S155
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Protein Length
Full Length of Mature Protein
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Molecular Weight
18.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Basic fibroblast growth factor (bFGF), also known as FGF-2, is a key member of the fibroblast growth factor family, playing a crucial role in various biological processes such as cell proliferation, differentiation, and angiogenesis. The importance of bFGF in wound healing and tissue repair has sparked significant interest in its therapeutic potential. Research has indicated that bFGF can stimulate fibroblast activity, enhance vasculogenesis, and promote collagen synthesis, making it a valuable candidate for regenerative medicine and tissue engineering. Recombinant bFGF has been produced in various expression systems, enabling the study of its biological functions and therapeutic applications. The ability to produce this growth factor in a controlled manner allows for the development of bFGF-based treatments for conditions such as chronic wounds, ischemic diseases, and even certain cancers. Ongoing studies aim to optimize its delivery and efficacy, exploring combinations with biomaterials and other growth factors to maximize its regenerative capabilities. As the understanding of bFGF’s mechanisms of action expands, its integration into clinical practices holds promise for advancing therapeutic strategies in regenerative medicine.
