Analytical Data
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基因名
PIAS3
- Application
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别名
ZMIZ5; Zinc Finger,MIZ-Type Containing 5; E3 SUMO-protein ligase PIAS3
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6X2
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表达区间
Val11~Leu280
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分子量
60KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIAS3 (Protein Inhibitor of Activator of Transcription 3) is a key multifunctional protein that plays a crucial role in the regulation of various biological processes, including immune response, apoptosis, and cell differentiation. As a member of the PIAS family, PIAS3 primarily functions as an E3 ubiquitin ligase, modulating the activity of transcription factors, particularly STAT3 (Signal Transducer and Activator of Transcription 3). The dysregulation of STAT3 signaling has been implicated in several diseases, including cancer, autoimmune disorders, and chronic inflammation, making PIAS3 a potential target for therapeutic intervention. Research on recombinant PIAS3 protein has gained attention due to its role in understanding the molecular mechanisms underlying these diseases. By producing recombinant PIAS3, researchers aim to elucidate its interaction with STAT3 and other signaling pathways, providing insights into its regulatory functions. Furthermore, studying PIAS3 in a controlled environment allows for the exploration of its potential as a biomarker or therapeutic target. Given the complex interplay of the immune system and tumor microenvironment, investigating PIAS3's role could yield valuable information for developing novel treatment strategies, particularly in cancers characterized by aberrant STAT3 activation. Overall, the study of recombinant PIAS3 protein is essential for advancing our knowledge of its biological functions and exploring its implications in health and disease.
