Recombinant Mouse OCTN2 Protein，His & GST

OCTN2 (Nominally known as SLC22A4) is a crucial member of the organic cation/carnitine transporter family, predominantly expressed in the kidney and small intestine, where it plays a vital role in the reabsorption and transport of carnitine, an essential factor for fatty acid metabolism and energy production. Defects in OCTN2 are linked to primary systemic carnitine deficiency (PSCD), a disorder that results in impaired fatty acid oxidation, leading to debilitating symptoms and metabolic crises. Given the transporter’s significant role in carnitine homeostasis, research has focused on the structural and functional characteristics of OCTN2, particularly regarding its mechanisms of substrate transport and regulation. Recombinant OCTN2 protein is leveraged in studies to elucidate these processes, allowing for the investigation of its transport kinetics, substrate specificity, and interactions with various molecules, such as pharmaceuticals and environmental toxins. Advances in this field promise to enhance our understanding of carnitine metabolism and may inform therapeutic strategies for conditions arising from OCTN2 dysfunction, thereby addressing PSCD and other metabolic disorders linked to impaired carnitine transport. The development of OCTN2 as a recombinant protein also opens avenues for drug screening and the potential design of targeted therapies aimed at mitigating the effects of transportation deficiencies.