Analytical Data
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Gene name
DOG1
- Application
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Alternative Names
DOG1; YHR044C2-deoxyglucose-6-phosphate phosphatase 1; 2-DOG-6-P 1; 2-deoxyglucose-6-phosphatase 1; EC 3.1.3.68
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Species
Saccharomyces cerevisiae
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Source
Yeast
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P38774
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Expression Region
1-246aa
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Molecular Weight
29.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DOG1, or Discovered on Gastrointestinal stromal tumors 1, is a protein that has garnered significant attention due to its role in the pathophysiology of gastrointestinal stromal tumors (GISTs). GISTs are the most common mesenchymal tumors of the gastrointestinal tract, often driven by mutations in the KIT or PDGFRA genes, which lead to constitutive activation of receptor tyrosine kinases. DOG1 serves as a vital marker for diagnosing GISTs, as it is overexpressed in these tumors, making it a potential target for therapeutic interventions. Research into the recombinant DOG1 protein has facilitated the development of diagnostic tools and therapeutic strategies, enhancing our understanding of GIST biology. Studies have explored the structural characteristics and biological functions of DOG1, uncovering its interactions with other cellular components that regulate tumor growth and survival pathways. The recombinant production of DOG1 protein not only aids in elucidating its role in GISTs but also paves the way for exploring its therapeutic potential in combination with existing treatments. Overall, the investigation of DOG1 recombinant protein holds promise for improving GIST diagnosis and therapy, reflecting the need for targeted strategies in managing this challenging malignancy.
