Analytical Data
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Gene name
PCDHb10
- Application
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UN67
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Expression Region
Thr64~Asp270
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDHb10, or protocadherin beta 10, is a member of the protocadherin family, which plays a crucial role in neuronal development and synaptic functions. This protein is primarily expressed in the brain and is believed to be involved in cell-cell adhesion processes, influencing neuronal connectivity and potentially impacting various neurodevelopmental and neuropsychiatric disorders. Researchers have focused on the structure and function of PCDHb10 to understand its role in mediating neuronal assembly and maintaining synaptic integrity. Recent studies have indicated its importance in modulating calcium signaling and interacting with other synaptic proteins, making it a candidate of interest for investigating mechanisms underlying cognitive functions and deficits. The development of recombinant PCDHb10 protein is essential for biophysical studies, enabling researchers to explore its structural properties and interactions at a molecular level. Furthermore, understanding its function can lead to insights into the pathogenesis of diseases like autism spectrum disorders and schizophrenia, where alterations in synaptic dynamics are often observed. The ongoing research on PCDHb10 not only sheds light on its potential therapeutic implications but also enhances the understanding of complex neural networks in health and disease. Thus, unraveling the characteristics and mechanisms of PCDHb10 will facilitate the development of novel strategies for intervention in neurodevelopmental disorders.
