Analytical Data
-
Gene name
CNTNAP3
- Application
-
Alternative Names
CASPR3; CNTNAP3A; Cell recognition molecule Caspr3
-
Species
Human
-
Source
E. coli
-
Tag
N- His & GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9BZ76
-
Expression Region
Gly26~Lys349
-
Molecular Weight
66kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CNTNAP3, or Caspr-like protein 3, is a member of the neurexin superfamily, which is critical for neuronal development and synaptic function. Research indicates that CNTNAP3 plays an essential role in the formation and maintenance of the axo-glial junctions in the nervous system, facilitating communication between neurons and glial cells. Mutations or dysregulation of CNTNAP3 have been implicated in various neurological disorders, including autism spectrum disorders and schizophrenia, highlighting its importance in neurodevelopmental processes. Recombination and expression of CNTNAP3 protein in a laboratory setting allow researchers to study its structural and functional properties, as well as its interactions with other proteins in the neural circuitry. By generating recombinant CNTNAP3, scientists can investigate its role in cell adhesion, signaling pathways, and the overall impact on synaptic plasticity. Furthermore, understanding CNTNAP3's function can potentially lead to therapeutic targets for treating neurodevelopmental disorders, making it a significant focus in neuroscience research. This ongoing investigation emphasizes the necessity of characterizing the biochemical and biophysical properties of CNTNAP3, paving the way for deeper insights into its involvement in neural connectivity and the pathophysiology of associated disorders.
