Analytical Data
-
Gene name
PLCh2
- Application
-
Alternative Names
PLCL4; PLCeta2; RP3-395M20.1; PLC-eta2; Phospholipase C-like 4; Phosphoinositide phospholipase C-like 4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O75038
-
Expression Region
Met1~His257
-
Molecular Weight
30kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLCh2, or phospholipase C delta 2, is an enzyme that plays a pivotal role in various cellular processes, including signal transduction, cell proliferation, and apoptosis. As a member of the phospholipase C family, PLCh2 is involved in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG), two critical second messengers that modulate calcium signaling and protein kinase activation. The study of PLCh2 is particularly significant in the context of its potential implications in cancer biology, neurobiology, and cardiovascular diseases. Researchers have identified that aberrant expression and activity of PLCh2 can contribute to tumorigenesis and metastasis, highlighting the enzyme as a potential therapeutic target. Moreover, PLCh2's involvement in neuronal signaling pathways raises interest in its function in neurodegenerative disorders. As recombinant protein technology advances, the production and characterization of PLCh2 in a laboratory setting have gained momentum, facilitating in-depth studies of its enzymatic properties and regulatory mechanisms. Understanding PLCh2's structure-function relationship could provide valuable insights into its role in health and disease, paving the way for novel therapeutic interventions.
