Analytical Data
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Gene name
SLC29A2
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简介
The SLC29A2 protein is a bidirectional uniporter that maintains cellular nucleoside homeostasis. As a Na(+)-independent transporter, it facilitates the transport of various nucleosides and nucleobases, including inosine, adenosine, uridine, thymidine, cytidine, and guanosine. SLC29A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC29A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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Species
Human
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Source
HEK293
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Tag
N-MBP;C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14542
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Expression Region
A2-L456
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AA Sequence
ARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAELLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
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Protein Length
Partial
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Molecular Weight
93.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC29A2, a member of the solute carrier family, encodes the concentrative nucleoside transport protein responsible for the uptake of nucleosides, which are critical for various cellular processes, including DNA and RNA synthesis. Mutations in SLC29A2 have been linked to certain genetic disorders, such as the autosomal recessive condition known as limb-girdle muscular dystrophy and other neurological defects, highlighting the protein's significance in maintaining cellular nucleoside levels. The study of SLC29A2 recombinant protein is essential for understanding its structure, function, and mechanisms of action. By obtaining this protein, researchers aim to investigate its transport kinetics, substrate specificity, and potential interactions with other cellular components. Furthermore, insights gained from characterizing SLC29A2 could pave the way for the development of novel therapeutic strategies to address disorders associated with its dysfunction. Overall, the exploration of SLC29A2 and its recombinant form holds promise for unraveling the complexities of nucleoside transport and its implications in health and disease.
