Analytical Data
-
基因名
TOP3b
- Application
-
别名
TOP3B1; A topoisomerase III beta-1
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O95985
-
表达区间
Met1~Asp250
-
分子量
32kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TOP3B is a member of the topoisomerase family, which plays a crucial role in DNA replication and repair by alleviating torsional strain in the DNA helix. Research on TOP3B has gained momentum due to its involvement in critical cellular processes and its potential links to various diseases, including cancer. Unlike other topoisomerases, TOP3B specifically interacts with RNA and is implicated in the regulation of transcription by forming complexes with RNA-binding proteins. Its unique function in modulating RNA metabolism makes it an intriguing target for understanding how dysregulation of this process can contribute to tumorigenesis and other pathologies. Recent studies have highlighted the protein's role in maintaining genomic stability and its importance in cellular responses to stress. Furthermore, the exploration of TOP3B's biochemical properties and regulation mechanisms could provide insights into novel therapeutic approaches, especially in the context of cancer treatment where topoisomerase inhibitors have been successfully employed. Overall, the investigation of TOP3B's functions and interactions within the cell is vital for unraveling the complexities of gene expression regulation and its implications in disease.
