Analytical Data
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Gene name
ABCA7
- Application
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Alternative Names
ABC-A7; ABCA-SSN; ABCX; Autoantigen SS-N; Macrophage ABC transporter
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IZY2
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Expression Region
Glu53~Leu249
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Molecular Weight
51.0kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCA7 (ATP-binding cassette sub-family A member 7) is a crucial gene implicated in various physiological processes, particularly in the context of lipid metabolism and immune response. Recent studies have highlighted its significance in the pathology of Alzheimer’s disease, as variations in the ABCA7 gene have been associated with increased risk of developing this neurodegenerative disorder. Research indicates that ABCA7 plays a role in the clearance of amyloid-beta peptides, which aggregate and form plaques in the brains of Alzheimer's patients. Additionally, ABCA7 is involved in the modulation of inflammation and phagocytosis in microglial cells, further linking it to neuroimmune interactions. Understanding the structure and function of ABCA7 recombinant proteins is essential for elucidating its role in these biological processes. Experimental studies utilizing recombinant ABCA7 proteins aim to characterize its function, interactions with lipids, and influence on cellular pathways, providing insights into its contribution to Alzheimer’s and other diseases. The ongoing research seeks to establish ABCA7 as a potential target for therapeutic interventions, highlighting the necessity for a deeper understanding of its molecular mechanisms and implications in human health.
