Analytical Data
-
基因名
ABCB6
- Application
-
别名
ABC-B6; PRP; ABC; ABC14; MTABC3; Umat; ATP-Binding Cassette Half-Transporter; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9NP58
-
表达区间
Ile590~Arg842
-
分子量
31kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCB6 is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in the cellular transport of various substrates across membranes. It has garnered significant interest in biomedical research due to its association with several physiological and pathological processes, particularly in the transport of porphyrins, which are key intermediates in heme biosynthesis. Abnormal ABCB6 function has been implicated in disorders such as porphyrias and certain types of anemia, highlighting its importance in heme metabolism. Furthermore, studies have suggested that ABCB6 may influence drug metabolism and resistance, making it relevant in pharmacogenomics and cancer research. Research on recombinant ABCB6 protein has advanced our understanding of its structure and function, enabling the investigation of substrate specificity and transport mechanisms. By producing and characterizing recombinant ABCB6, researchers aim to elucidate its roles in disease and potentially identify therapeutic targets. Understanding ABCB6's function at a molecular level may contribute to the development of novel strategies for treating related disorders and improving drug efficacy.
