Analytical Data
-
Gene name
ABCB6
- Application
-
Alternative Names
ABC-B6; PRP; ABC; ABC14; MTABC3; Umat; ATP-Binding Cassette Half-Transporter; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9NP58
-
Expression Region
Ile590~Arg842
-
Molecular Weight
31kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCB6 is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in the cellular transport of various substrates across membranes. It has garnered significant interest in biomedical research due to its association with several physiological and pathological processes, particularly in the transport of porphyrins, which are key intermediates in heme biosynthesis. Abnormal ABCB6 function has been implicated in disorders such as porphyrias and certain types of anemia, highlighting its importance in heme metabolism. Furthermore, studies have suggested that ABCB6 may influence drug metabolism and resistance, making it relevant in pharmacogenomics and cancer research. Research on recombinant ABCB6 protein has advanced our understanding of its structure and function, enabling the investigation of substrate specificity and transport mechanisms. By producing and characterizing recombinant ABCB6, researchers aim to elucidate its roles in disease and potentially identify therapeutic targets. Understanding ABCB6's function at a molecular level may contribute to the development of novel strategies for treating related disorders and improving drug efficacy.
