Analytical Data
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基因名
ABCC9
- Application
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别名
ABC-C9; SUR2; ABC37; CMD1O; Sulfonylurea receptor 2
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种属
Human
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表达系统
E. coli
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标签
Two N- s, His- & SUMO-
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60706
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表达区间
Arg593~Phe834
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分子量
65kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCC9, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in various physiological processes, including cellular signaling and ion transport. This protein is known to form a complex with sulfonylurea receptors, critically influencing pancreatic ATP-sensitive potassium channels (KATP channels) and thereby regulating insulin secretion. Dysregulation of ABCC9 has been implicated in various diseases, including diabetes and heart conditions, making it a potential therapeutic target. Research on recombinant ABCC9 protein has gained attention as it can facilitate the elucidation of its structure-function relationships and interactions with ligands. Additionally, studying the recombinant protein can help in understanding the mechanisms of KATP channel modulation and its role in cellular homeostasis. Such investigations could lead to the development of novel drugs aimed at correcting the dysfunctional signaling pathways associated with ABCC9, potentially offering new treatment options for metabolic disorders.
