Analytical Data
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Gene name
ABCC9
- Application
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Alternative Names
ABC-C9; SUR2; ABC37; CMD1O; Sulfonylurea receptor 2
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Species
Human
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Source
E. coli
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Tag
Two N- s, His- & SUMO-
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60706
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Expression Region
Arg593~Phe834
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Molecular Weight
65kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCC9, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in various physiological processes, including cellular signaling and ion transport. This protein is known to form a complex with sulfonylurea receptors, critically influencing pancreatic ATP-sensitive potassium channels (KATP channels) and thereby regulating insulin secretion. Dysregulation of ABCC9 has been implicated in various diseases, including diabetes and heart conditions, making it a potential therapeutic target. Research on recombinant ABCC9 protein has gained attention as it can facilitate the elucidation of its structure-function relationships and interactions with ligands. Additionally, studying the recombinant protein can help in understanding the mechanisms of KATP channel modulation and its role in cellular homeostasis. Such investigations could lead to the development of novel drugs aimed at correcting the dysfunctional signaling pathways associated with ABCC9, potentially offering new treatment options for metabolic disorders.
