Analytical Data
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基因名
KIFC1
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简介
KIFC1 Protein, a minus end-directed microtubule-dependent motor, is crucial for bipolar spindle formation. It also participates in early endocytic vesicle movement, indicating a role in intracellular transport. Additionally, KIFC1 regulates cilium formation and structure, interacting with NUBP1, NUBP2, and PPP1R42, suggesting potential involvement in processes related to nucleotide binding and protein dephosphorylation. KIFC1 Protein, Human is the recombinant human-derived KIFC1 protein, expressed by E. coli , with tag free.
- 应用
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别名
KIFC1; Kinesin-like protein KIFC1; Kinesin-like protein 2; Kinesin-related protein HSET
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BW19
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表达区间
Q305-K673
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氨基酸序列
QELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANRK
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蛋白长度
Partial
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分子量
39.8 KDa as predicted
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIFC1, or kinesin family member C1, is an essential motor protein that plays a crucial role in the transport of cellular cargo along microtubules, particularly during mitosis and organelle positioning. Its importance in cellular processes has garnered significant interest in the research community, especially in the context of cancer, where aberrant expression or function of KIFC1 can contribute to tumorigenesis and metastasis. Researchers have been investigating the structure-function relationship of KIFC1 to understand its mechanistic role in intracellular transport and cell division. This includes the development of recombinant KIFC1 proteins to study their biochemical properties, motor activity, and interactions with cargo and microtubules. Understanding these aspects could lead to new therapeutic strategies targeting KIFC1 in cancer treatment. Additionally, recombinant KIFC1 proteins can serve as valuable tools in cell biology to elucidate the pathways associated with kinesin motor proteins, aiding in the discovery of novel regulatory mechanisms governing cellular dynamics.
