Analytical Data
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Gene name
PTPN4
- Application
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Alternative Names
PTPMEG; PTPMEG1; Protein-tyrosine phosphatase MEG1
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29074
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Expression Region
Asn616~Lys926
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPN4, or protein tyrosine phosphatase, non-receptor type 4, is an essential regulator of various cellular processes, including signal transduction, cell growth, and differentiation. It plays a pivotal role in modulating the activity of tyrosine kinases, thereby influencing multiple signaling pathways critical for immune responses and neuronal functions. Dysregulation of PTPN4 has been implicated in various diseases, including autoimmune disorders and cancers, making it a significant focus of research. The recombinant expression of PTPN4 allows for in-depth studies of its functional mechanisms and interactions with other proteins. By generating purified PTPN4 proteins, researchers can perform biochemical assays, structural analyses, and functional assays to elucidate the phosphatase's role in pathological conditions. The study of PTPN4 as a therapeutic target is also promising, as modulating its activity could lead to innovative treatment strategies for diseases where PTPN4 dysregulation is a contributing factor. Through the exploration of PTPN4's biological significance and its potential therapeutic applications, researchers aim to enhance the understanding of cellular signaling networks and develop novel intervention methods.
