Analytical Data
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基因名
KRT85
- Application
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别名
Hair keratin K2.12 (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25) (KRTHB5)
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种属
Human
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表达系统
Yeast
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78386
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表达区间
1-507aa
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分子量
57.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT85, also known as keratin 85, is a member of the keratin family of fibrous proteins, which play crucial roles in the structural integrity and functionality of epithelial tissues. The research background surrounding KRT85 primarily focuses on its role in skin and hair follicle biology, as keratins are vital components of the cytoskeleton in epithelial cells, contributing to mechanical resilience and barrier functions. Studies have indicated that KRT85 may be involved in various skin disorders and may impair wound healing processes when expressed abnormally. Additionally, the regulation of KRT85 expression during keratinocyte differentiation suggests its importance in skin development and pathology. Recent advancements in molecular biology techniques have allowed for the detailed analysis of KRT85 in both healthy and diseased states, facilitating the understanding of its role in keratinocyte behavior, including proliferation and apoptosis. Furthermore, due to its potential links to conditions such as ichthyosis and other keratinization disorders, KRT85 is of significant interest in dermatological research. Investigating the roles and mechanisms of KRT85 not only enhances our understanding of keratinocyte biology but also holds promise for developing targeted therapeutic strategies for skin-related disorders. As research continues to evolve, the functional characterization of KRT85 may lead to novel insights into the cellular mechanisms underlying skin homeostasis and disease, positioning it as a critical focus in the fields of dermatology and molecular medicine.












