Analytical Data
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Gene name
Maspin
- Application
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Alternative Names
SERPINB5; PI5; Protease Inhibitor 5; Serpin Peptidase Inhibitor Clade B Member 5
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P36952
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Expression Region
Met1~Pro375
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Molecular Weight
46kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Maspin, a serine protease inhibitor belonging to the family of serpin proteins, has garnered significant attention in cancer research due to its dual role as a tumor suppressor. Initially identified in the context of breast cancer, Maspin is expressed at high levels in normal epithelial tissues but often shows reduced expression in various malignancies, suggesting its potential role in tumor progression and metastasis. Studies have revealed that Maspin functions by inhibiting cell migration and invasion, thus contributing to the suppression of tumor spread. Moreover, its ability to interact with several cellular pathways highlights its importance in regulating cell adhesion and inducing apoptosis in cancer cells. The recombinant production of Maspin has enabled researchers to investigate its biological functions in detail, including its mechanisms of action and therapeutic potential. By providing a purified source of this protein, recombinant Maspin facilitates the exploration of its efficacy in preclinical models, offering insights into its role as a biomarker for cancer prognosis and a potential target for novel therapeutic strategies. As the understanding of Maspin's function continues to evolve, studies are increasingly focusing on its utility not only in breast cancer but also in other malignancies, emphasizing its promise in advancing cancer biology and treatment approaches.
