Analytical Data
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Gene name
CD3eAP
- Application
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Alternative Names
CAST; ASE-1; PAF49; Antisense To ERCC 1; DNA-Directed RNA Polymerase I Subunit RPA34; RNA polymerase I-associated factor PAF49
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q76KJ5
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Expression Region
Cys7~Leu399
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Molecular Weight
51kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD3eAP is a crucial component in the context of T cell biology, particularly in the assembly and signaling of the T cell receptor (TCR) complex. This protein plays a vital role in the immune response by facilitating the correct formation and stability of TCR-CD3 complexes, which are essential for T cell activation and function. Research into CD3eAP has garnered attention due to its potential implications in immunological diseases and therapies, including cancer and autoimmune disorders. Its expression patterns and interactions with other signaling molecules provide insights into T cell maturation and activation processes. Furthermore, understanding the structure and function of CD3eAP can pave the way for novel therapeutic strategies aimed at modulating T cell responses. Therefore, recombinant studies of CD3eAP have become fundamental in unraveling the complexities of T cell signaling and in developing innovative approaches for immunotherapy, targeting not only the mechanisms of T cell-mediated immunity but also addressing challenges in designing effective vaccines and treatments for various diseases.
