Analytical Data
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基因名
U2A/SNRPA
- Application
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别名
U1A; U1-A; Mud1; SNRP-A
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q62189
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表达区间
Ala93~Lys287
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
U2A/SNRPA, a crucial component of the splicing machinery in eukaryotic cells, plays a vital role in the regulation of pre-mRNA splicing. As a part of the U2 snRNP complex, U2A/SNRPA is involved in the recognition of the branch point sequence in introns, facilitating the assembly of the spliceosome. The study of U2A/SNRPA has garnered attention due to its implications in various cellular processes and its association with several diseases, including cancer and genetic disorders. The protein's structure and function have been extensively investigated, revealing insights into its interactions with RNA and other spliceosomal components. Additionally, the reconstitution of U2A/SNRPA in a controlled experimental setup allows researchers to probe its biochemical properties and functional dynamics comprehensively. Understanding the mechanisms governing U2A/SNRPA function is instrumental in deciphering the intricacies of RNA processing and may contribute to the development of targeted therapies for splicing-related diseases. Given the protein's significance in gene expression regulation, ongoing research aims to elucidate its precise role in splicing catalysis and its potential as a therapeutic target.
