Analytical Data
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Gene name
SAFB
- Application
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Alternative Names
HET; HAP; SAFB1; Scaffold attachment factor B1; Hsp27 ERE-TATA Binding Protein; HSP27 estrogen response element-TATA box-binding protein
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Species
Mouse
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
D3YXK2
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Expression Region
Ala2~Ser235
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Molecular Weight
70kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of SAFB (Scaffold Attachment Factor B) recombinant proteins is rooted in the exploration of their significant roles in gene regulation and cellular processes. SAFB is a multifunctional nuclear protein that interacts with various factors involved in transcriptional regulation and RNA processing. Research has shown that SAFB is crucial for the organization of nuclear architecture and influences the expression of key genes, which can have implications in development and disease. The ability of SAFB to bind to scaffold regions of chromatin underscores its importance in maintaining genomic integrity and regulating gene expression at multiple levels. Furthermore, due to its role in various cellular pathways, including proliferation and apoptosis, SAFB has emerged as a potential biomarker and therapeutic target in cancer research. The recombinant expression of SAFB allows scientists to study its structure-function relationships, investigate its interactions with other proteins, and evaluate its potential as a therapeutic target. Overall, understanding SAFB's molecular mechanisms requires robust research into its recombinant form, paving the way for new insights into its involvement in health and disease states.
