Analytical Data
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Gene name
TPPP2
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简介
The TPPP2 protein may be a regulator of microtubule dynamics and is critical for sperm motility. Unlike other family members, TPPP2 lacks microtubule bundling activity, suggesting a unique functional role. TPPP2 Protein, Human (His) is the recombinant human-derived TPPP2 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Tubulin polymerization-promoting protein family member 2; Protein p25-beta; TPPP/p18; C14orf8
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P59282
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Expression Region
M1-K170
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Protein Length
Full Length
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TPPP2 (Tubulin Polymerization Promoting Protein 2) is a member of the TPPP family of proteins known for their involvement in microtubule dynamics and neuronal function. This protein has garnered attention due to its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where microtubule stability is compromised. Research indicates that TPPP2 can promote the polymerization of tubulin, thereby contributing to the maintenance of cellular architecture in neurons. Additionally, aberrant expression of TPPP2 has been associated with various cancers, suggesting a broader biological significance beyond the nervous system. Scientists are particularly interested in its structure-function relationship, as understanding the molecular mechanics of TPPP2 could unveil therapeutic targets for diseases characterized by microtubule instability. The recombinant production of TPPP2 has been a focus in recent studies, allowing for detailed biochemical analyses and the exploration of its interactions with tubulin and other cellular components. This recombinant approach facilitates the investigation of TPPP2 in model systems, advancing our understanding of its functional roles and potential implications in health and disease.
