Analytical Data
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Gene name
TMED1
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse TMED1 at 0.5 μg/mL (100 μL/well) can bind Human ST2. The ED50 for this effect is 2.39 μg/mL. Measured by its binding ability in a functional ELISA. Immobilized Mouse TMED1 at 0.5 μg/mL (100 μL/well) can bind Human ST2. The ED50 for this effect is 2.39 μg/mL.
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Alternative Names
Transmembrane emp24 domain-containing protein 1; Interleukin-1 receptor-like 1 ligand; Tp24; IL1RL1L; IL1RL1LG
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
B2RRM5
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Expression Region
G25-N194
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Protein Length
Partial
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Molecular Weight
56-60 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMED1, also known as Transmembrane Emp24 Protein Transport Domains 1, is a member of the p24 family of proteins, which are implicated in vesicular transport and endoplasmic reticulum-Golgi trafficking. The importance of TMED1 in cellular processes has garnered attention due to its role in protein sorting, and its involvement in various pathophysiological conditions, including cancer and neurodegenerative diseases. Research has shown that TMED1 functions as a chaperone for the transport of glycoproteins and is essential for maintaining cellular homeostasis. Abnormal expression or mutations in TMED1 have been linked to disrupted protein trafficking dynamics, leading to cellular stress and disease progression. Given its critical functions, TMED1 has become a focus of interest for understanding the molecular mechanisms underlying cellular transport processes. Moreover, studies exploring TMED1 as a potential biomarker or therapeutic target are emerging, highlighting its relevance in disease management, particularly in conditions where protein misfolding and trafficking abnormalities are prominent. The generation of recombinant TMED1 protein is crucial for such studies, as it allows for the investigation of its structure-function relationships and interactions with other cellular components. Understanding TMED1's role at the molecular level could provide insights into developing targeted therapies for diseases associated with impaired protein transport mechanisms.
