Analytical Data
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Gene name
PURA
- Application
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Alternative Names
PUR-A; PUR1; PUR-ALPHA; PURALPHA; Transcriptional activator protein Pur-alpha; Purine-rich single-stranded DNA-binding protein alpha
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q00577
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Expression Region
Met1~Asp322
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Molecular Weight
39kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PURA protein, encoded by the PURA gene, is a member of the purine-rich element-binding protein family, playing a critical role in RNA metabolism and translational regulation. Recent studies have highlighted its significance in neuronal development and function, with mutations in the PURA gene being associated with neurodevelopmental disorders such as intellectual disability and autism spectrum disorders. Researchers are increasingly focusing on PURA due to its involvement in various cellular processes, including cell proliferation, differentiation, and stress response. The protein's ability to bind RNA and potentially regulate gene expression adds to its importance in understanding complex neurological conditions. Investigating PURA's structure, function, and interaction with other molecular partners can shed light on its role in both normal neurodevelopment and disease states. This ongoing research aims to uncover potential therapeutic targets and strategies for interventions in disorders linked to PURA dysfunction, highlighting the protein as a vital focus in the broader context of neurogenetics and molecular neurology.
