Analytical Data
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Gene name
ANG1
- Application
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Alternative Names
ANG1; ANGAngiogenin-1; EC 3.1.27.-
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Species
Bovine
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10152
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Expression Region
24-148aa
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Molecular Weight
18.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Angiogenin (ANG1) is a ribonuclease that plays a crucial role in angiogenesis, the formation of new blood vessels, which is vital for various physiological processes such as wound healing and tumor growth. In recent years, research has intensified around the recombinant expression of ANG1 due to its potential therapeutic applications. Understanding ANG1's structure and function can provide insights into its role in diseases characterized by aberrant angiogenesis, such as cancer, diabetic retinopathy, and age-related macular degeneration. Moreover, recombinant ANG1 can be harnessed to study the underlying mechanisms of angiogenesis and cellular responses to stress, as it is involved in regulating cell survival, proliferation, and differentiation. The development of recombinant ANG1 also presents an opportunity to explore its use as a therapeutic agent, with promising implications in promoting tissue regeneration and enhancing the efficacy of cancer treatments by modulating the tumor microenvironment. Ongoing studies are focused on optimizing the expression and purification of ANG1 to facilitate its use in both basic research and clinical applications, thereby advancing our understanding of angiogenesis and its implications in health and disease.
