Analytical Data
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基因名
ABCA12
- Application
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别名
ABC-A12; LI2; ICR2B; Ichthyosis Congenita II,Lamellar Ichthyosis B; ATP-binding cassette sub-family A member 12
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86UK0
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表达区间
Val1346~Thr1577
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCA12 is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in lipid metabolism and cellular homeostasis. It is predominantly expressed in the epidermis and is essential for the formation of the skin barrier. Mutations in the ABCA12 gene are linked to a rare and severe skin disorder called harlequin ichthyosis, characterized by extreme skin dryness and scaling. Researchers have focused on the characterization of ABCA12 recombinant proteins to gain insights into its structure-function relationships and the molecular mechanisms underlying its role in keratinocyte lipid transport and epidermal differentiation. By utilizing various recombinant protein expression systems, scientists aim to produce functional ABCA12 proteins for biochemical and biophysical analysis, which may provide critical information about the domains responsible for substrate binding and transport. Understanding the dynamics of ABCA12 can pave the way for the development of therapeutic strategies for ichthyosis and related skin disorders, as well as advance the broader field of ABC transporter research, highlighting the importance of lipid transport in human health.
