Analytical Data
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基因名
S100A1
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简介
S100A1 is a small calcium-binding protein that plays critical roles in multiple processes, including Ca(2+) homeostasis and cardiomyocyte regulation. Elevated intracellular Ca(2+) triggers conformational changes in S100A1, thereby interacting with key proteins in cardiomyocytes such as RYR1, RYR2, ATP2A2 and F1-ATPase. S100A1 Protein, Human (C-His) is the recombinant human-derived S100A1 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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别名
Protein S100-A1; S-100 protein alpha chain; S100A; S100A1; S100-alpha
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P23297
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表达区间
M1-S94
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蛋白长度
Full Length
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分子量
10.03 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S100A1 is a member of the S100 protein family, characterized by its calcium-binding ability and involvement in various cellular processes, including inflammation, differentiation, and cell cycle regulation. Research has identified S100A1 as pivotal in cardiac function and muscle contraction, making it a critical target in the study of cardiomyopathies and other cardiovascular diseases. Its expression is primarily observed in cardiac and skeletal muscle tissues, and alterations in S100A1 levels have been linked to heart failure and other pathological conditions. The production of recombinant S100A1 protein has facilitated detailed studies of its structure-function relationships, biochemical properties, and interactions with other cellular proteins. This has profound implications for therapeutic applications, where modulation of S100A1 activity could offer new avenues for treating cardiovascular diseases. Additionally, the study of S100A1 involves understanding its role in signaling pathways, notably those related to calcium homeostasis and oxidative stress, further contributing to our comprehension of muscle biology and disease mechanisms. Overall, the exploration of S100A1 as a recombinant protein serves as a vital tool in advancing both basic and clinical research in the context of cardiac health and disease.
