Analytical Data
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Gene name
CEP110
- Application
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Alternative Names
FAN; CP110; CEP1; Centriolin; Centrosomal Protein 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z7A1
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Expression Region
Ile2101~Arg2325
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Molecular Weight
34kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CEP110 is a key protein that plays a critical role in the regulation of ciliogenesis and the maintenance of centrosomal structure. As a centrosomal protein, CEP110 is involved in the assembly and function of centrioles, which are essential for proper cell division and the formation of cilia. Abnormalities in CEP110 expression and function have been linked to various ciliopathies and cancer, highlighting its significance in cellular processes. Recent studies have demonstrated that CEP110 interacts with other essential proteins involved in cell cycle regulation and ciliogenesis, suggesting its multifaceted role in cellular dynamics. The recombinant expression of CEP110 provides a valuable tool for elucidating its function and interactions, allowing researchers to investigate its mechanistic roles in normal and pathological contexts. Overall, understanding the biochemical properties and functions of CEP110 through recombinant protein studies could pave the way for novel therapeutic strategies in diseases associated with centrosomal dysfunction.
