Analytical Data
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Gene name
BRD8
- Application
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Alternative Names
SMAP; p120; SMAP2; Skeletal muscle abundant protein 2; Thyroid hormone receptor coactivating protein of 120 kDa
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8R3B7
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Expression Region
Ala797~Lys951
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Molecular Weight
21kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BRD8 (Bromodomain Containing 8) is a protein that belongs to the bromodomain and extraterminal (BET) family, which plays a crucial role in regulating gene expression through its interaction with acetylated lysines on histones and non-histone proteins. Recent studies have highlighted the significance of BRD8 in various biological processes, including cell proliferation, differentiation, and apoptosis. Its involvement in the regulation of key oncogenic pathways has drawn considerable interest from researchers, particularly in the context of cancer biology. For instance, BRD8 has been found to modulate the expression of genes linked to tumor growth and metastasis, making it a potential therapeutic target. The recombinant expression of BRD8 protein has enabled scientists to investigate its structural properties, binding affinities, and functional roles more effectively. By producing BRD8 in recombinant systems, researchers can examine its interactions with various molecular partners and elucidate its mechanisms of action in greater detail. This understanding is pivotal for exploring small molecule inhibitors that could disrupt BRD8's interactions in diseases such as cancer, thereby providing new avenues for treatment. As studies continue to unveil the complexities of BRD8's functions and interactions, it is becoming increasingly clear that this protein is a key player in the regulatory networks that maintain cellular homeostasis and contribute to disease states.
